Palladium-Catalyzed Spirocyclization through C−H Activation and Regioselective Alkyne Insertion

Angewchem
Palladium-Catalyzed Spirocyclization through C−H Activation and Regioselective Alkyne Insertion
Hyung Yoon, Martin Rölz, Felicitas Landau and Prof. Dr. Mark Lautens
 A Pd-catalyzed spirocyclization involving a sequential carbopalladation, intramolecular C−H activation, and a highly regioselective alkyne insertion to afford spirooxindoles and spirodihydrobenzofurans has been achieved. The spirocyclic products were generated in good to excellent yields with complete regiocontrol in a readily scalable procedure.

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