Trifluoromethylation of Alkyl Radicals in Aqueous Solution

Jacs
Trifluoromethylation of Alkyl Radicals in Aqueous Solution: The copper-mediated trifluoromethylation of alkyl radicals is described. The combination of Et3SiH and K2S2O8 initiates the radical reactions of alkyl bromides or iodides with BPyCu(CF3)3 (BPy = 2,2′-bipyridine) in aqueous acetone at room temperature to afford the corresponding trifluoromethylation products in good yield.

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