Selective sp3 C–H alkylation via polarity-match-based cross-coupling

Nature
Selective sp3 C–H alkylation via polarity-match-based cross-coupling
Chip Le,  Yufan Liang, Ryan W. Evans, Ximing Li & David W. C. MacMillan

Nature 547, 79–83 doi:10.1038/nature22813
Using a triple catalytic approach, a selective sp 3 C–H alkylation is demonstrated that is applicable in late-stage functionalization of pharmaceutical compounds.

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