Cobalt Catalysis for Enantioselective Cyclobutanone Construction

Jacs
Cobalt Catalysis for Enantioselective Cyclobutanone Construction: Over the past 40 years, intramolecular hydroacylation has favored five-membered rings, in preference to four membered rings. Herein, we report a catalyst derived from earth-abundant cobalt that enables preparation of cyclobutanones, with excellent regio-, diastereo-, and enantiocontrol, under mild conditions.

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