Direct Catalytic Desaturation of Lactams Enabled by Soft Enolization

Jacs
Direct Catalytic Desaturation of Lactams Enabled by Soft Enolization: A direct catalytic method is described for the α,β-desaturation of N-protected lactams to their conjugated unsaturated counterparts under mildly acidic conditions. The reaction is consistently operated at room temperature and tolerates a wide range of functional groups, showing reactivity complementary to that of prior desaturation methods.

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