Sulfone–Metal Exchange and Alkylation of Sulfonylnitriles

Angewchem
Sulfone–Metal Exchange and Alkylation of Sulfonylnitriles: The first general sulfone–metal exchange is described. Treating substituted 2‐pyridylsulfonylacetonitriles with either BuLi or Bu3MgLi generates metalated nitriles that efficiently intercept a variety of electrophiles to afford quaternary nitriles.

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