Palladium‐Catalyzed Enantioselective Redox‐Relay Heck Alkynylation of Alkenols to Access Propargylic Stereocenters

Angewchem
Palladium‐Catalyzed Enantioselective Redox‐Relay Heck Alkynylation of Alkenols to Access Propargylic Stereocenters: An enantioselective redox‐relay Heck alkynylation of di‐ and trisubstituted alkenols to construct propargylic stereocenters is disclosed using a new pyridine oxazoline ligand. This strategy allows direct access to chiral β-alkynyl carbonyl compounds employing allylic alcohol substrates in contrast to more traditional conjugate addition methods.

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