Palladium‐Catalyzed Cascade sp2 C−H Functionalization/Intramolecular Asymmetric Allylation: From Aryl Ureas and 1,3‐Dienes to Chiral Indolines

Angewchem
Palladium‐Catalyzed Cascade sp2 C−H Functionalization/Intramolecular Asymmetric Allylation: From Aryl Ureas and 1,3‐Dienes to Chiral Indolines: A chiral PdII‐catalyzed cascade sp2 C−H functionalization/intramolecular asymmetric allylation reaction is reported. A new chiral sulfoxide–oxazoline (SOX) ligand bearing single chiral center on the sulfur was identified as the optimal ligand for the reaction, being efficient both in the C−H cleavage step and the stereocontrol of the allylation step.

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