Ligand‐Enabled Auxiliary‐Free Meta‐C−H Arylation of Phenylacetic Acids

Angewchem
Ligand‐Enabled Auxiliary‐Free Meta‐C−H Arylation of Phenylacetic Acids: The meta‐C−H arylation of free phenylacetic acid was realized using 2‐carbomethoxynorbornene (NBE‐CO2Me) as a transient mediator. Both the modified norbornene and the mono‐protected 3‐amino‐2‐hydroxypyridine type ligand are crucial for this auxiliary-free meta-C−H arylation reaction.

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