In‐Cell Dual Drug Synthesis by Cancer‐Targeting Palladium Catalysts

Angewchem
In‐Cell Dual Drug Synthesis by Cancer‐Targeting Palladium Catalysts: Transition metals have been successfully applied to catalyze non‐natural chemical transformations within living cells, with the highly efficient labeling of subcellular components and the activation of prodrugs. In vivo applications, however, have been scarce, with a need for the specific cellular targeting of the active transition metals. Here, we show the design and application of cancer-targeting palladium catalysts, with their specific uptake in brain cancer (glioblastoma) cells, while maintaining their catalytic activity.

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