Enantioselective Total Synthesis of ( )-Wortmannin

Jacs
Enantioselective Total Synthesis of ( )-Wortmannin: A concise and enantioselective total synthesis of the potent PI3K inhibitor (+)-wortmannin is described. A Pd-catalyzed cascade reaction was first developed to connect a synthon derived from Hajos–Parrish ketone to a furan moiety. The subsequent Friedel–Crafts alkylation of the β-position of a furan ring to an epoxide was optimized to establish the C10 quaternary center. 

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