Enantioselective β-Protonation of Enals via a Shuttling Strategy

Jacs
Enantioselective β-Protonation of Enals via a Shuttling Strategy: Remote asymmetric protonation is a longstanding challenge due to the small size of protons. Reactions involving electron-deficient olefins pose a further difficulty due to the electrophilic nature of these substrates. We report a shuttling system that delivers a proton in a highly enantioselective manner to the β-carbon of enals using a chiral N-heterocyclic carbene (NHC) catalyst.

No comments:

Post a Comment

Popular Posts