Decarboxylative alkenylation

  • Decarboxylative alkenylation

     Jacob T. Edwards, Rohan R. Merchant, Kyle S. McClymont, Kyle W. Knouse,Tian Qin, Lara R. Malins, Benjamin Vokits, Scott A. Shaw, Deng-Hui Bao, Fu-Liang Wei, Ting Zhou, Martin D. Eastgate & Phil S. Baran
    Nature 545, 213–218 doi:10.1038/nature22307 

    Starting with alkyl carboxylic acids, a simple olefin synthesis using any substitution pattern or geometry, based on amide-bond synthesis with nickel- or iron-based catalysis, is described.


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