Corona[5]arenes Accessed by a Macrocycle‐to‐Macrocycle Transformation Route and a One‐Pot Three‐Component Reaction

Angewchem
Corona[5]arenes Accessed by a Macrocycle‐to‐Macrocycle Transformation Route and a One‐Pot Three‐Component Reaction: Corona[5]arenes, a novel type of macrocyclic compound that is composed of alternating heteroatoms and para‐arylenes, were synthesized efficiently by two distinct methods. In a macrocycle‐to‐macrocycle transformation approach, S6-corona[3]arene[3]tetrazine underwent sequential SNAr reactions with HS-C6H4-X-C6H4-SH (X=S, CH2, CMe2, SO2, and O) to produce the corresponding corona[3]arene[2]tetrazines.

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