Construction of Chiral Tetrahydro‐β‐Carbolines: Asymmetric Pictet–Spengler Reaction of Indolyl Dihydropyridines

Angewchem
Construction of Chiral Tetrahydro‐β‐Carbolines: Asymmetric Pictet–Spengler Reaction of Indolyl Dihydropyridines: A highly efficient synthesis of the enantioenriched tetrahydro‐β‐carbolines was developed by using a chiral phosphoric acid catalyzed Pictet–Spengler reaction of indolyl dihydropyridines. The reaction proceeds under mild reaction conditions to afford the desired chiral tetrahydro-β-carbolines in good to excellent yields (up to 96 %) and high enantioselectivities (up to 99 % ee).

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