Concise Total Synthesis of Dioncophylline E through an ortho‐Arylation Strategy

Concise Total Synthesis of Dioncophylline E through an ortho‐Arylation Strategy: The first total synthesis of the potent antimalarial 7,3′‐linked naphthylisoquinoline alkaloid dioncophylline E (1) has been completed. The synthesis proceeds in 12 steps (longest linear sequence) and in 15 % overall yield. Key transformations include an ortho-arylation of a naphthol with an aryllead triacetate to construct the sterically hindered biaryl bond, and a three-step sequence to stereoselectively generate the trans-1,3-dimethyl-1,2,3,4-tetrahydroisoquinoline moiety.

No comments:

Post a Comment

Popular Posts