Chiral Phosphoric Acid-Catalyzed Kinetic Resolution via Amide Bond Formation

Jacs
Chiral Phosphoric Acid-Catalyzed Kinetic Resolution via Amide Bond Formation: We describe the kinetic resolution of a readily available 2-pyridyl ester via an amide bond formation catalyzed by a chiral Brønsted acid. A chiral phosphoric acid bearing a 2,4,6-trimethyl-3,5-dinitrophenyl group at the 3,3′-position enabled this transformation with high selectivities.

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