Anti-Markovnikov Hydroarylation of Unactivated Olefins via Pyridyl Radical Intermediates

Jacs
Anti-Markovnikov Hydroarylation of Unactivated Olefins via Pyridyl Radical Intermediates: The intermolecular alkylation of pyridine units with simple alkenes has been achieved via a photoredox radical mechanism. This process occurs with complete regiocontrol, where single-electron reduction of halogenated pyridines regiospecifically yields the corresponding radicals in a programmed fashion, and radical addition to alkene substrates occurs with exclusive anti-Markovnikov selectivity.

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