Metal-Free Electrophilic Phosphination/Cyclization of Alkynes

Jacs
Metal-Free Electrophilic Phosphination/Cyclization of Alkynes: Metal-Free Electrophilic Phosphination/Cyclization of Alkynes
A metal-free electrophilic phosphination reaction has been developed. Electrophilic phosphorus species generated in situ from secondary phosphine oxides and Tf2O smoothly couple with alkynes possessing pendant nucleophiles to afford the corresponding phosphinated cyclization products in good yield.
 

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