Enantioselective Silver and Amine Co‐catalyzed Desymmetrizing Cycloisomerization of Alkyne‐linked Cyclohexanones

Angewchem
Enantioselective Silver and Amine Co‐catalyzed Desymmetrizing Cycloisomerization of Alkyne‐linked Cyclohexanones: A silver(I) and amine co‐catalyzed desymmetrization of 4‐propargylamino cyclohexanones for the direct enantioselective synthesis of 2‐azabicyclo[3.3.1]nonanes is described. Exploiting reactivity arising from dual activation of the pendant terminal alkyne by silver(I) and the ketone moiety through transient enamine formation, this synthetically relevant transformation is easy to perform, efficient and broad in scope.

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