A Concise, Efficient and Scalable Total Synthesis of Thapsigargin and Nortrilobolide from (R)-(−)-Carvone - Journal of the American Chemical Society (ACS Publications)

A Concise, Efficient and Scalable Total Synthesis of Thapsigargin and Nortrilobolide from (R)-(−)-Carvone - Journal of the American Chemical Society (ACS Publications)
A concise, efficient and scalable synthesis of thapsigargin and nortrilobolide from commercially available (R)-(−)-carvone was developed. Our synthetic strategy is inspired by nature’s carbon–carbon bond formation sequence, which facilitates the construction of a highly functionalized sesquiterpene lactone skeleton in five steps via an enantioselective ketone alkylation and a diastereoselective pinacol cyclization. 

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