Rh(III)-Catalyzed meta-C–H Olefination Directed by a Nitrile Template - Journal of the American Chemical Society (ACS Publications)

Rh(III)-Catalyzed meta-C–H Olefination Directed by a Nitrile Template - Journal of the American Chemical Society (ACS Publications)
A range of Rh(III)-catalyzed ortho-C–H functionalizations have been developed; however, extension of this reactivity to remote C–H functionalizations through large-ring rhodacyclic intermediates has yet to be demonstrated. Herein we report the first example of the use of a U-shaped nitrile template to direct Rh(III)-catalyzed remote meta-C–H activation via a postulated 12-membered macrocyclic intermediate.
 

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