Enantioselective Alkyne Conjugate Addition Enabled by Readily Tuned Atropisomeric P,N-Ligands - Journal of the American Chemical Society (ACS Publications)

Enantioselective Alkyne Conjugate Addition Enabled by Readily Tuned Atropisomeric P,N-Ligands - Journal of the American Chemical Society (ACS Publications)

The transformation provides access to highly useful chiral β-alkynyl Meldrum’s acid building blocks as demonstrated by an efficient enantioselective synthesis of the preclinical agent OPC 51803.

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