Remote C−H alkylation and C−C bond cleavage enabled by an in situ generated palladacycle

Remote C−H alkylation and C−C bond cleavage enabled by an in situ generated palladacycle
Juntao Ye, Zhihao Shi, Theresa Sperger, Yoshifumi Yasukawa, Cian Kingston, Franziska Schoenebeck & Mark Lautens
Nature Chemistry doi:10.1038/nchem.2631
Existing methods for C–H activation depend on preinstalled directing groups, the removal of which poses a practical limitation on the use of these reactions in synthesis. Now, a remote-selective C−H alkylation reaction of arenes using an in situ generated spiropalladacycle has been shown to furnish benzofurans and indoles without the need for a directing group.

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