Rapid heteroatom transfer to arylmetals utilizing multifunctional reagent scaffolds

Rapid heteroatom transfer to arylmetals utilizing multifunctional reagent scaffolds
Hongyin Gao, Zhe Zhou, Doo-Hyun Kwon, James Coombs, Steven Jones, Nicole Erin Behnke, Daniel H. Ess & László Kürti
Nature Chemistry doi:10.1038/nchem.2672
The direct transfer of primary amino and hydroxyl groups to arylmetals in a scalable and environmentally friendly fashion remains a formidable synthetic challenge. Here, it is demonstrated that bench-stable N–H and N–alkyl oxaziridines can be used as efficient multifunctional reagents, without deprotonation, for the direct primary amination and hydroxylation of (hetero)arylmetals.

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