Palladium-Catalyzed Asymmetric α-Arylation of Alkylnitriles - Journal of the American Chemical Society (ACS Publications)

Palladium-Catalyzed Asymmetric α-Arylation of Alkylnitriles - Journal of the American Chemical Society (ACS Publications)
Asymmetric arylation of alkylnitriles forms quaternary stereocenters in good enantiocontrol for the first time. A lithium heterodimer consisting of an alkylnitrile anion and a disilylamide ion is the actual species responsible for the stereodetermining transmetalation in the catalytic cycle.
 

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