New ligands for nickel catalysis from diverse pharmaceutical heterocycle libraries

Natchem
New ligands for nickel catalysis from diverse pharmaceutical heterocycle libraries - pp1126 - 1130
Eric C. Hansen, Dylan J. Pedro, Alexander C. Wotal, Nicholas J. Gower, Jade D. Nelson, Stephane Caron & Daniel J. Weix
doi:10.1038/nchem.2587
Access to large phosphine ligand libraries has become an essential tool for the application of metal-catalysed reactions industrially, but these existing libraries are not well suited to new catalytic methods based on non-precious metals (for example, Ni, Cu and Fe). The development of the requisite nitrogen- and oxygen-based ligand libraries lags far behind that of the phosphines and the development of new libraries is anticipated to be time consuming. Here we show that this process can be dramatically accelerated by mining for new ligands in a typical pharmaceutical compound library that is rich in heterocycles.  

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