F– Nucleophilic-Addition-Induced Allylic Alkylation - Journal of the American Chemical Society (ACS Publications)

F– Nucleophilic-Addition-Induced Allylic Alkylation - Journal of the American Chemical Society (ACS Publications)
Herein we present a novel strategy based on palladium-catalyzed allylic alkylation by taking advantage of the nucleophilic addition of external fluoride onto gem-difluoroalkenes as the initiation step. The merit of this protocol is highly appealing, as it enables a formal allylation of trifluoroethylarene derivatives through the in situ generation of β-trifluorocarbanions, which otherwise are deemed to be problematic in deprotonative allylation.
 

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