Direct assembly of multiply oxygenated carbon chains by decarbonylative radical–radical coupling reactions

Direct assembly of multiply oxygenated carbon chains by decarbonylative radical–radical coupling reactions
Kengo Masuda, Masanori Nagatomo & Masayuki Inoue
Nature Chemistry 8, 1105–1111doi:10.1038/nchem.2636
Pentoses and hexoses represent important structural motifs in bioactive secondary metabolites, though their synthesis often requires several elongation steps. Now, a method for radical–radical coupling reactions of sugar derivatives enables the single-step preparation of the oxygenated carbon chains of several natural products, including sagittamide D, maitotoxin and hikizimycin.

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