Copper Catalyzed sp3 C–H Etherification with Acyl Protected Phenols - Journal of the American Chemical Society (ACS Publications)

Copper Catalyzed sp3 C–H Etherification with Acyl Protected Phenols - Journal of the American Chemical Society (ACS Publications)
A variety of acyl protected phenols AcOAr participate in sp3 C-H etherification of substrates R-H to give alkyl aryl ethers R-OAr employing tBuOOtBu as oxidant with copper(I) β-diketiminato catalysts [CuI]. Although 1°, 2°, and 3° C-H bonds may be functionalized, selectivity studies reveal a preference for the construction of hindered, 3° C-OAr bonds.
 

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