Aldehydes as alkyl carbanion equivalents for additions to carbonyl compounds

Aldehydes as alkyl carbanion equivalents for additions to carbonyl compounds
Haining Wang, Xi-Jie Dai & Chao-Jun Li
Nature Chemistry doi:10.1038/nchem.2677
Methods utilizing renewable feedstocks are critical to accessing molecules of industrial importance in light of the present ecological and economic climate. Here, it is shown that umpolung reactivity of carbonyl compounds can be used for nucleophilic additions to yield a diverse array of valuable alcohols as an alternative to using stoichiometric organometallic reagents.

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