A decarboxylative approach for regioselective hydroarylation of alkynes

Natchem
A decarboxylative approach for regioselective hydroarylation of alkynes - pp1144 - 1151
Jing Zhang, Ruja Shrestha, John F. Hartwig & Pinjing Zhao
doi:10.1038/nchem.2602
 Regioselective activation of aromatic C–H bonds is a long-standing challenge for arene functionalization reactions such as the hydroarylation of alkynes. A new catalytic method for regioselective alkyne hydroarylation with benzoic acid derivatives during which the carboxylate functionality directs the alkyne to the ortho-C–H bond with elimination in situ to form a vinylarene product.

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