Catalytic activation of carbon-carbon bonds in cyclopentanones

  • Catalytic activation of carbon–carbon bonds in cyclopentanones
    Ying Xia, Gang Lu, Peng Liu & Guangbin Dong
    Nature 539, 546–550 doi:10.1038/nature19849

    In the chemical industry, it is often necessary to activate carbon–carbon bonds in order to synthesize complex organic molecules, but this is challenging when starting with simple five- or six-membered carbon rings; a new method uses a rhodium pre-catalyst and an amino-pyridine co-catalyst, enabling an overall energetically favourable reaction that involves activation of carbon–carbon bonds plus activation of carbon–hydrogen bonds.
     

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